By David Nutt, Liam Nestor
A part of the Oxford Psychiatry Library sequence, this pocketbook is a transparent and finished evaluate of the mind technological know-how underpinning habit and the way this is helping clarify the present and destiny therapeutics for the diversity of addictions, utilizing complete color photographs to reinforce knowing. Addiction specializes in the character of dependancy as a mind affliction that features a diversity of other behavioural qualities akin to impulsivity and present dependence, and discusses the serious position of kinetic and pharmacological components. The textual content explains how the first pharmacological ambitions of gear of abuse are actually understood, the relation to the variable nature of habit to diversified elements, and the way this can bring about new ways to remedy.
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Additional info for Addiction (Oxford Psychiatry Library)
Psychopharmacology (Berl), 219, 501–10. Goldstein RZ, Woicik PA, Moeller SJ, et al. (2010). Liking and wanting of drug and non-drug rewards in active cocaine users: the STRAP-R questionnaire. Journal of Psychopharmacology, 24, 257–66. Koob GF and Volkow ND (2010). Neurocircuitry of addiction. Neuropsychopharmacology, 35, 217–38. Zorick T, Nestor L, Miotto K, et al. (2010). Withdrawal symptoms in abstinent methamphetamine-dependent subjects. Addiction, 105, 1809–18. 52 Chapter 4 Neurobiological processes in addiction Key points The brain controls necessary motivational and cognitive processes.
Based on data from Davies et al . 2011 Impact on family and social networks—including human and emotional costs, such as breakdown of marital and family relationships, poverty, loss of employment, domestic and child abuse, and homelessness. References and Further Reading Davies C, English L, Stewart C, et al. (2011). United Kingdom drug situation: annual report to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) 2011. United Kingdom Focal Point at the Department of Health, London.
Dopamine binding to D2R is generally thought to encode information related to expected reward value and the reward itself. A number of other neurotransmitter systems influence VS reward circuitry. Inhibitory gamma-aminobutyric acid (GABA) neurons are located in the VS. GABA neurons project from the NAcc to the ventral pallidum (VP) via the striato-pallidal pathway. Glutamate is an excitatory neurotransmitter. Glutamate projections from the PFC to the VS are important for learning about rewards (see Learning and memory below).
Addiction (Oxford Psychiatry Library) by David Nutt, Liam Nestor