Download e-book for iPad: Alzheimer's disease and related disorders annual, 2002 by Jeffrey L Cummings, Serge Gauthier

By Jeffrey L Cummings, Serge Gauthier

ISBN-10: 1841842346

ISBN-13: 9781841842349

Given the improvement of recent healing thoughts and items, Serge Gauthier and Jeffrey Cummings have compiled an inventory of latest themes so as to be of curiosity essentially to neurologists targeting Alzheimer's sickness, and in addition to psychiatrists and geriatricians. The participants, all revered of their subspecialties, have written updated, comprehensively referenced chapters which should offer assistance in addition to stimulate dialogue on the place present therapy is heading.

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In: Mattson MP, Estus S, eds. Programmed Cell Death: Cellular and Molecular Mechanisms. Elsevier Science, 2000:67–92. 10. Talanian RV, Quinlan C, Trautz S et al. Substrate specificities of caspase family proteases. J Biol Chem 1997; 272:9677–9682. 11. Thornberry NA, Rano TA, Peterson EP et al. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J Biol Chem 1997; 272:17907–17911. Alzheimers CH02 32 17/6/02 2:36 pm Page 32 Apoptosis and its role in Alzheimer’s Disease 12.

3 Transgenic models of Alzheimer’s disease Josephine Nalbantoglu Before the elucidation of the genetic mutations involved in familial Alzheimer’s disease (AD), most of the studies of AD were based on the pathological characteristics of brain tissue obtained at autopsy from patients that had been diagnosed clinically as suffering from dementia. These neuropathological examinations usually revealed the presence of extracellular amyloid plaques, intracellular neurofibrillary tangles (NFT) as well as important cell loss in specific regions of the brain.

Roy N, Deveraux QL, Takahashi R et al. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. Embo J 1997; 16:6914– 6925. 38. LeBlanc A, Liu H, Goodyer C et al. Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer’s disease. J Biol Chem 1999; 274:23426–23436. 39. Seidl R, Bajo M, Bohm K et al. Neuronal apoptosis inhibitory protein (NAIP)-like immunoreactivity in 33 brains of adult patients with Down syndrome. J Neural Transm Suppl 1999; 57:283–291. 40.

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Alzheimer's disease and related disorders annual, 2002 by Jeffrey L Cummings, Serge Gauthier

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